Practiced medicine, Philadelphia. Manager of the lottery (appointed by Continental Congress), 1776-1777. Surgeon, quartermaster general, Pennsylvania Militia, 1779.
Member medical staff Philadelphia General Hospital, 1779-1780. Delegate Continental Congress from Philadelphia, 1785. Trustee U. State of Pennsylvania, 1789, University of Pennsylvania, 1791-1801.
Member American Philosophical Society, 1792. An organizer 1st Democratic Society in American, 1793. Alderman Philadelphia, 1801.