After studying medicine at Saint Bartholomew"s Hospital, he became the institution"s assistant surgeon in 1770. Due to the temporary incapacity of one of the hospital"s surgeons, Earle performed one-third of Saint Bartholomew"s operations between 1776 and 1784. At the end of this phenomenal feat, Earle was elected to be a surgeon on 22 May 1784 and remained until 1815.
Just two years later, he was appointed surgeon-extraordinary to George III. In March, 1794 he was elected a fellow of the Royal Society.
He was knighted in 1807. Earle write a memoir of Pott that was subsequently attached to his complete works (1790) and a biography of William Austin.
Earle was renowned for his surgery skills, particularly in lithotomy. He also published several medical works: A Treatise on the Hydrocele (1791, with additions in 1793, 1796, and 1805), Practical Observations on the Operation for Stone (1793), A New Method of Operation for Cataract (1801), and Letter on Fractures of the Lower Limbs (1807).
Royal Society.