Jiri Novotny, Czech biophysicist. Achievements include patent for single-chain T cell receptor fragments; for alpha-helical heterotetramers; for peptides derived from the obese gene; for mutant penicillin G acylases; development of empirical free energy potential, of molecular theory of protein antigenicity; identification of C1q binding site on antibody molecules; research on secondary structure prediction algorithm.
Scientist Institute Organic Chemistry & Biochemistry, Prague, 1970-1977. Senior scientist Institute Molecular Genetics, Czech Academy of Sciences, 1971-1979. From assistant to associate professor Harvard Medical School, Boston, 1980-1988.
Director department Bristol-Myers Squibb Research Institute, Princeton, New Jersey, 1988-1998. Visiting scientist Oxford University, England, 1979. Visiting scholar department molecular biology Princeton University, since 1993.
Director research Pasteur Institute, Paris, 1987. Adjunct professor University Pennsylvania, Philadelphia, 1989-1995. Consultant Creative Biomolecules Inc., Hopkinton, Massachusetts, 1987-1988, Roussel UCLAF, Romainville, France, 1987, Howard Hughes Medical Institute, Boston, 1986-1987.
Member science advisory board Procept, Inc., Cambridge, 1989-1992, Center Biomolecular Simulation Columbia University, New York City, 1994-1998, Novalon Inc., Durham, North Carolina, since 1999.
Achievements include patent for single-chain T cell receptor fragments. For alpha-helical heterotetramers. For peptides derived from the obese gene.
For mutant penicillin G acylases. Development of empirical free energy potential, of molecular theory of protein antigenicity. Identification of C1q binding site on antibody molecules.
Research on secondary structure prediction algorithm.
1970 - 1977
1971 - 1979
1980 - 1988
1988 - 1998