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Jiri Novotny

Jiri Novotny, Czech biophysicist. Achievements include patent for single-chain T cell receptor fragments; for alpha-helical heterotetramers; for peptides derived from the obese gene; for mutant penicillin G acylases; development of empirical free energy potential, of molecular theory of protein antigenicity; identification of C1q binding site on antibody molecules; research on secondary structure prediction algorithm.

Background

  • Novotny, Jiri was born on December 15, 1943 in Kladno, Czech Republic. Came to the United States, 1979. Son of Jaroslav and Eva (Foustkova) Novotny.

  • Education

    • Doctor rerum naturalium, Charles University, Prague, Czechoslovakia, 1970. Doctor of Philosophy, Charles University, Prague, Czechoslovakia, 1970.

    Career

    • Scientist Institute Organic Chemistry & Biochemistry, Prague, 1970-1977. Senior scientist Institute Molecular Genetics, Czech Academy of Sciences, 1971-1979. From assistant to associate professor Harvard Medical School, Boston, 1980-1988.

      Director department Bristol-Myers Squibb Research Institute, Princeton, New Jersey, 1988-1998. Visiting scientist Oxford University, England, 1979. Visiting scholar department molecular biology Princeton University, since 1993.

      Director research Pasteur Institute, Paris, 1987. Adjunct professor University Pennsylvania, Philadelphia, 1989-1995. Consultant Creative Biomolecules Inc., Hopkinton, Massachusetts, 1987-1988, Roussel UCLAF, Romainville, France, 1987, Howard Hughes Medical Institute, Boston, 1986-1987.

      Member science advisory board Procept, Inc., Cambridge, 1989-1992, Center Biomolecular Simulation Columbia University, New York City, 1994-1998, Novalon Inc., Durham, North Carolina, since 1999.

    Major achievements

    • Achievements include patent for single-chain T cell receptor fragments. For alpha-helical heterotetramers. For peptides derived from the obese gene.

      For mutant penicillin G acylases. Development of empirical free energy potential, of molecular theory of protein antigenicity. Identification of C1q binding site on antibody molecules.

      Research on secondary structure prediction algorithm.

    Works

    • Contributor articles to journals, including proceedings National Academy of Sciences, Nature, Biochemistry. Contributing author: Advances in Protein Chemistry, 1996, Encyclopedia Molecular Biology, 1995, Encyclopedia Immunology, 1993, Current Opinions in Structural Biology, 1997.

    Membership

    Member American Physical Society, American Society Biological Chemists, American Biophysics Society, American Chemical Society, Princeton Chess Club, Belle Meade Friends of Music.

    Connections

    • Married Jarmila Novotny, February 26, 1967. 1 child, Paula.
    • father: Jaroslav Novotny
    • mother: Eva (Foustkova) Novotny
    • spouse: Jarmila Novotny
    • child: Paula Novotny
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    Born December 15, 1943
    (age 73)
    Nationality
    Ethnicity:
    • 1970
      Charles University
    • 1970
      Charles University
    • 1970 - 1977
      Scientist, Institute Organic Chemistry & Biochemistry
      Prague, Hlavni mesto Praha, Czech Republic
    • 1971 - 1979
      senior, scientist Institute Molecular Genetics
    • 1980 - 1988
      from assistant, to associate professor Harvard Medical School
      Boston, Massachusetts, United States
    • 1988 - 1998
      director, department Bristol-Myers Squibb Research Institute
      Princeton, New Jersey, United States