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Kuo-Chen Chou

Kuo-Chen Chou, Chinese biophysical chemist. Fellow American Institute Chemistry; member American Association for the Advancement of Science, New York Academy of Sciences, Biophysical Society, American Chemical Society, Sigma Xi.

Background

  • Chou, Kuo-Chen was born on August 14, 1938 in Guangdong, China. Came to the United States, 1980. Son of Hsiu-Chi Chou and Bi-Kun Luo.

  • Education

    • Bachelor of Science, Nanking University, China, 1960. Master of Science, Nanking University, China, 1962. Doctor of Philosophy, Shanghai (Peoples Republic China) Institute Biochemistry, 1976.

      Doctor of Science, Kyoto University, Japan, 1983.

    Career

    • Junior scientist Shanghai Institute Biochemistry, Chinese Academy of Sciences, 1976-1978, associate professor, 1978-1979. Visiting associate, professor Chemical Center Lund (Sweden) University, 1979-1980. Visiting associate professor Max-Planck Institute Biophysics Chemistry, Göttingen, Federal Republic Germany, 1979-1980.

      Visiting associate professor chemistry Cornell University, Ithaca, New York, 1980-1983, senior scientist Baker Laboratory, 1984-1985. Professor biophysics University Rochester, 1985—1986. Senior scientist Eastman Kodak Company, Rochester, 1986-1987, Upjohn Laboratories, Kalamazoo, 1987—1992, senior principal scientist, 1993—1999, research advisor, 1999—2002.

      Senior research adviser Pharmacia & Upjohn, since 1995, Pfizer, since 2002. Founding president and chief scientist Gordon Institute Life Science, since 2003. Honorary president, chairman scientific committee Tianjin Institute Bioinformatics and Drug Discovery, China, 2003—2007.

      Advisory professor Shanghai Jiao Tong University, since 2004, Tonghai University, since 2004, Northwestern Polytechnic University, since 2007, Guangx University, since 2007. Editor-in-chief Natural Science, 2009, Health, since 2009.

    Major achievements

    • Achievements include research in bioinformatics, protein conformation and folding. Graph theory in chemical reaction systems. Enzyme kinetics; DNA codon usage analysis.

      Prediction of enzyme functional class. Prediction of protein subcellular localization. Prediction membrane protein type, prediction of signal pettides, prediction of protease type, prediction of enzyme functional class, prediction protien-protien interaction, system biology.

      Structure and function of antifreeze protein. Prediction of Human Immunodeficiency Virus protease cleavage site. Low-frequency collective motions of biomacromolecules and their biological functions.

      Structures of growth hormone and membrane proteins, proton-pumping mechanism of membrane proteins, inhibition kinetics of Human Immunodeficiency Virus reverse transcriptase, structure and binding site of adhesion proteins, apoptosis, human GFAT, G-protein couple receptors. GABA and GPCR receptors, cyclin-dependent kinases, molecular mechanism of Alzheimer's Disease. BACE1/BACE2, Alpha-7 nicotinic acetylcholine receptor, Ions channels, binding mechanism of coronavirus main proteinase with ligands.

      Drug design for Severe Acute Respiratory Syndrome therapy. Prediction signal peptides and their cleavage sites.

    Works

    • Editor Journal Molecular Science, 1983-1986, Progress in Physics, 1981-1985, bioinformatics section Amino Acids, 2004-2007. Associate editor: Medicinal Chemistry, since 2004, Journal Theoretical Biology, since 2005. Regional editor: Western American, Protein and Peptide Letters, since 2006.

      Member editorial board Current Peptide and Protein Science, since 2000, Cancer Therapy, since 2003, Current Proteomics, since 2007, Journal Biophysics, since 2008. Editorial board member Intedisciplinary Science, since 2007. Editor-in-chief Open Bioinformatics Journal, since 2008.

      Contributor more than 380 research articles and review papers to professional jours.edito.

    Membership

    Fellow American Institute Chemistry. Member American Association for the Advancement of Science, New York Academy of Sciences, Biophysical Society, American Chemical Society, Sigma Xi.

    Connections

    • Married Wei-Zhu Zhong, April 12, 1968. 1 child, James Jeiwen Chou.
    • father: Hsiu-Chi Chou
    • mother: Bi-Kun Luo
    • spouse: Wei-Zhu Zhong
    • child: James Jeiwen Chou
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    Born August 14, 1938
    Nationality
    Ethnicity:
    • 1960
      Nanking University
    • 1962
      Nanking University
    • 1976
      Shanghai (Peoples Republic China) Institute Biochemistry
    • 1983
      Kyoto University
    • 1976 - 1978
      Junior scientist, Shanghai Institute Biochemistry
    • 1979 - 1980
      visiting associate, professor Max-Planck Institute Biophysics Chemistry
      Göttingen, Niedersachsen, Germany, Germany
    • 1979 - 1980
      visiting associate, Chemical Center Lund (Sweden) University
    • 1979 - 1980
      professor, Chemical Center Lund (Sweden) University
    • 1980 - 1983
      visiting associate, professor chemistry Cornell University
      Ithaca, New York, United States
    • 1985 - 1986
      professor, biophysics University Rochester
    • 1986 - 1987
      senior, scientist Eastman Kodak Company
      Rochester, New York, United States
    • 1987 - 1992
      senior, scientist Eastman Kodak Company
      Kalamazoo, Michigan, United States
    • 1995
      senior, research adviser Pharmacia & Upjohn
    • 2002
      senior, research adviser Pharmacia & Upjohn
    • 2003 - 2007
      honorary president, scientific committee Tianjin Institute Bioinformatics and Drug Discovery
      China
    • 2003 - 2007
      chairman, scientific committee Tianjin Institute Bioinformatics and Drug Discovery
      China
    • 2003
      founding president, and chief scientist Gordon Institute Life Science
    • 2004
      advisory professor, Shanghai Jiao Tong University
    • 2004
      advisory professor, Shanghai Jiao Tong University
    • 2007
      advisory professor, Shanghai Jiao Tong University
    • 2007
      advisory professor, Shanghai Jiao Tong University
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