Margaret Irene Johnston, American science association administrator. Recipient Merit award National Institutes of Health, 1991, Outstanding Performance awards, 1989, 90, National Research Service award, 1978, Outstanding Performance award Uniformed Services University, 1987, Invention award Public Health Service, 1987, Undergrad. award American Chemical Society, 1972.
Postdoctoral associate Rega Institute for Medical Research, Leuven, Belgium, 1977-1978. Senior staff fellow National Institutes of Health, Bethesda, Maryland, 1978-1982. Assistant professor Uniformed Services University, 1982-1987, associate, adjunct professor, since 1987.
Chief, targeted drug Division of Acquired Immune Deficiency Syndrome National Institute Allied Infectious Diseases, 1987-1989, chief, development therapeutics branch Division Acquired Immune Deficiency Syndrome, 1989-1991, associate director Division Acquired Immune Deficiency Syndrome, since 1991. Ad hoc advisory board member of Acquired Immune Deficiency Syndrome Consortium of the Association of Minority Health Profession Schools, since 1990.
Achievements include elucidation of the antigenic structure of double stranded Ribonucleic acid's. Development of novel assay for detecting 2',5'-oligoadenylates and psoralen-modified nucleic acids. Purification of enzyme 2',5'-phosphodiesterase.
Invention of modified 2',5'-oligaodenylates with increased activities. First to quantification of 2',5'-oligaodenylates in tissues of animals treated with dsRNA. Research in Acquired Immune Deficiency Syndrome drug and vaccine discovery and development.