Her ability to mimic different accents and intonations was one of the key aspects of her career on the vaudeville stage, in the movies, and especially on radio.
In 1910, Florenz Ziegfeld heard her singing in a burlesque show and made her a regular performer in the Ziegfeld Follies. She appeared in musical shows in the 1920s and 1930s; her best-known songs included “Second-Hand Rose” and “My Man.”
Brice gained nationwide fame through a character, whom she originally created for one of her musical comedy acts; as Baby Snooks, a naughty, big-mouthed brat, Brice was known far and wide to musical comedy audiences and then to radio audiences from 1938 almost until her death.
Her three husbands included a noted gangster, Nicky Arstein, and a producer, Billy Rose.
In the 1960s a play about Brice’s life, "Funny Girl", introduced the new musical singing talent, Barbra Streisand. The play (1964) and subsequent movie (1968), together with the sequel, "Funny Lady" (1975), brought to life the career of Brice and helped to endear her to another generation of musical comedy lovers.