Born to a humble family in Madrid, Muñoz Grandes enrolled at the Toledo Infantry Academy while in his teens. Upon graduating, he was deployed to Morocco in 1915 and took part in the decisive Battle of Alhucemas. Muñoz Grandes fought for the Nacionales during the Spanish Civil War and was promoted to General, taking command in the Army of Africa.
He led the Spanish Legionnaires in the attack that of Málaga for the Nationales in February 1937.
In 1941, Muñoz Grandes was given command of the División Azul, Generalísimo Franco"s volunteer unit created for service under the Wehrmacht in Russia. Muñoz Grandes was well acquainted with the German military establishment, and attended several interviews with Wilhelm Canaris and Adolf Hitler.
He was recalled to Spain in December 1942. A promotion to Lieutenant General awaited him at home, and his post on the Eastern Front was taken up by Emilio Esteban Infantes.
Muñoz Grandes was appointed Captain-General of I Military District in 1945 and Minister of Defence in 1950.
He served as First Vice President of Spain from 1962 to 1967. Muñoz Grandes died in 1970.