(Co-authored Nature Chemical Biology report describing the...)
Co-authored Nature Chemical Biology report describing the discovery of adenosine thiamine triphosphate in Escherichia coli and its accumulation during carbon starvation.
https://doi.org/10.1038/nchembio867
2007
Alexander Fedorovich Makarchikov was born on December 13, 1964, in Shchuchin, in the Hrodzyenskaya Voblasts' of Belarus. He developed a scientific career in biochemistry and enzymology, maintaining professional connections between research institutions in Belarus and international collaborators in Belgium.
Makarchikov studied at Grodno State Agricultural University, completing his higher education on June 30, 1987. He subsequently pursued postgraduate education at the Institute of Biochemistry of the National Academy of Sciences of Belarus, completing the program in 1992. He continued advanced training in biology at Smolensk State Medical University and obtained a Doctor of Philosophy qualification in 1993. His early scientific specialization centered on enzymology and the metabolism of thiamine phosphate derivatives. In 1993, he also completed a dissertation on the isolation, purification, physicochemical properties, and kinetics of bovine-brain thiamine triphosphatase.
Makarchikov began his research career at the Institute of Biochemistry of the National Academy of Sciences of Belarus, where he worked successively as a junior researcher from 1993 to 1994, a researcher from 1995 to 1997, and a senior researcher from 1998 to 1999. From 2000 to 2005, he headed the laboratory of enzymology. His research during this period focused on thiamine triphosphate, thiamine triphosphatase activity, and the biochemical behavior of vitamin B1 derivatives in biological systems. He also collaborated with the Center for Cellular and Molecular Neurobiology at the University of Liège in Belgium, contributing to studies of thiamine metabolism in mammalian tissues and bacteria. From 2006, he continued his academic career at Grodno State Agricultural University as an assistant professor; later institutional descriptions identify him as an associate professor and head of the Department of Chemistry. His research contributed to the discovery of adenosine thiamine triphosphate in Escherichia coli and to the characterization of the enzyme responsible for its biosynthesis. He has continued publishing on thiamine metabolism, thiamine phosphate enzymes, and biochemical and medical aspects of vitamin B1 research, including a 2025 review co-authored with Pierre Wins and Lucien Bettendorff.
Contributed to the discovery of adenosine thiamine triphosphate, also known as thiaminylated ATP, the first reported adenine nucleotide containing vitamin B1.
Contributed to the identification and characterization of the enzyme responsible for adenosine thiamine triphosphate biosynthesis in Escherichia coli.
Conducted research on thiamine triphosphate, thiamine triphosphatase activity, and the metabolism and biological functions of vitamin B1 derivatives in bacteria, animals, and other biological systems.
Synthesis, physico-chemical properties and effect of adenosine thiamine triphosphate on vitamin B1 metabolism in the liver of alloxan diabetic rats
(Co-authored study of the synthesis, physicochemical prope...)
2022Copurification of chicken liver soluble thiamine monophosphatase and low molecular weight acid phosphatase
(Co-authored investigation of the purification and relatio...)
2017(Co-authored research showing that deletion of adenylate k...)
2002(Co-authored study characterizing a specific mammalian thi...)
2002(Co-authored research on tissue expression and messenger R...)
2004Identification of thiamine monophosphate hydrolyzing enzymes in chicken liver
(Co-authored study identifying enzymes that hydrolyze thia...)
2014(Co-authored study of the localization of a specific thiam...)
2004(Co-authored analysis of thiamine triphosphatase in pig ti...)
2005Adenosine thiamine triphosphate and adenosine thiamine triphosphate hydrolase activity in animal tissues
(Study of adenosine thiamine triphosphate and related hydr...)
2018(Co-authored biochemical characterization of recombinant h...)
2004(Study of thiamine triphosphatase activity in bovine kidney.)
1998(Research article co-authored with I. P. Chernikевич on th...)
1992(Research article co-authored with Alain Brans and Lucien ...)
2007(Co-authored Nature Chemical Biology report describing the...)
2007(Co-authored study of thiamine triphosphate accumulation i...)
2008(Review of thiamine transport, biosynthesis, degradation, ...)
2009(Review co-authored with Pierre Wins and Lucien Bettendorf...)
2025(Review co-authored with collaborators from Belarus and Be...)
2003Makarchikov is documented as the son of Nina Adamovna and Fedor Filippovich, the husband of Irina Frantsevna, and the father of Igor Alexandrovich. His scientific work has included collaboration with researchers at the University of Liège and the Institute of Biochemistry of the National Academy of Sciences of Belarus.
