Studies From the Saranac Laboratory for the Study of Tuberculosis: Studies in Immunity to Tuberculosis (Classic Reprint)
(Excerpt from Studies From the Saranac Laboratory for the ...)
Excerpt from Studies From the Saranac Laboratory for the Study of Tuberculosis: Studies in Immunity to Tuberculosis
A description Of the points Of resemblance and difference between Ro'mer's method of approach and my own is here necessary.
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Allen Kramer Krause was an American physician and investigator of tuberculosis. He remains a legend among tuberculosis investigators, because of his imaginative research and guidance in the subject, and also because of other talents: his remarkable scholarship, his encyclopedic mind, his knowledge of history, literature, art, and music, his book collecting, and his sometimes overriding intellectual dominance among men in his professional field.
Background
Allen Kramer Krause was born on February 13, 1881 in Lebanon, Pennsylvania, United States. His parents, George Derr Krause, the proprietor of a hardware store, and Jeanie Julia (Kramer) Krause, were of Pennsylvania German Protestant stock native in the region since colonial times. Allen was one of their three children.
Education
Allen's early education was in Lebanon public schools, with additional private instruction. His college and professional education was rapid. He matriculated at Brown University in 1898, graduated Bachelor of Arts in 1901, pursued further studies in biology at Brown and took a master's degree in 1902, began the study of medicine at Johns Hopkins University in 1903, and graduated with distinction in 1907. A special interest in pathology led him to commence work in that field, in the academic post of instructor, under one of America's most celebrated teachers, William Henry Welch. His studies were cut short after little more than a year, however, by the development of pulmonary tuberculosis.
Career
When Allen's tuberculosis was obvious, in December 1908, the Krauses moved to Saranac Lake, New York, then preeminent in the treatment and investigation of tuberculosis. Here Krause came under the influence of three of America's most distinguished physicians in this field, Edward L. Trudeau, Edward R. Baldwin, and Lawrason Brown. He himself soon gained comparable distinction. His recovery from tuberculosis was rapid, and in the succeeding years, as assistant director (from 1909) of the Saranac Laboratory, he carried out studies on resistance and immunity to tuberculosis that made him a leading authority. An untoward episode in 1914, the development of cancer of the bowel, for which operation was necessary, proved a severe inconvenience rather than a threat to life.
In 1916 he returned to Johns Hopkins University as associate professor of medicine, director of the Kenneth Dows Tuberculosis Laboratories, and physician-in-charge of the Phipps Tuberculosis Dispensary of the Johns Hopkins Hospital. Krause's thirteen years at Hopkins were the most productive in his life. He had the laboratory and clinical facilities to test his views, and he was fortunate in association with a younger, devoted laboratory investigator, Henry Stuart Willis. Their joint researches were classics of the period.
Extraordinarily facile in speaking and writing, Krause was prolific in publication and a remarkably effective lecturer. He became the most frequently sought author of tuberculosis chapters in the encyclopedic literature of the day. Beginning in 1916, Krause edited the American Review of Tuberculosis, founded that year by the National Tuberculosis Association, a large voluntary health-promoting organization, under the inspiration of the Saranac Lake physicians. This journal developed American research on the disease enormously, and gave Krause himself a ready forum. His own extensive reading, an extraordinarily retentive memory, and meticulous attention to accuracy and style made him an outstanding editor. He held numerous correlated positions, including the editorship of an American section in the British journal Tubercle.
In 1929 Krause left the Johns Hopkins Medical School to venture into the field of clinical medicine, as president of the Desert Sanatorium of Tucson, Arizona, with concomitant responsibilities as clinical professor of medicine at Stanford University and the University of Southern California. He continued to edit the American Review of Tuberculosis. In his editorial work there was no decline, but his success was not great in the other posts. For a time his popularity was undimmed, but he deteriorated steadily in health. Slight in stature and always frail, he had apparently driven himself too hard. Newcomers in his chosen field were refuting some of his work. Gradually he drifted into mental depression.
He returned to Baltimore and the Johns Hopkins Hospital in 1936, but continued to fail in health.
Achievements
Krause developed concepts that soon oriented this country's understanding of the pathogenesis of tuberculosis. His central concept was that the hypersensitivity (allergy) to tuberculo-protein, resulting from infection by the tubercle bacillus, fortified resistance to the disease.
(Excerpt from Studies From the Saranac Laboratory for the ...)
Connections
In his fourth year of medical school, on October 10, 1906, Krause had married Clara Fletcher of Providence, Rhode Island. She devoted her life to his needs, protecting his marginal health. They had three children: Gregory, Francis, and Fletcher.