By the time she reached high school, her foster mother arranged for her to stay in Chicago, where Amanda graduated from high school and attended the School of the Art Institute of Chicago. She then earned the John Quincy Adams fellowship for foreign study in 1952, and she chose to study sculpture with Jose De Creeft at the Instituto Allende in San Miguel de Allende, Mexico.
By the age of four, she had decided to become an artist. " At the age of eight, she was already selling her carvings. She ultimately earned her Master of Fine Arts degree from the School of the Art Institute of Chicago in 1952.
In 1953, the Cherokee Historical Association invited Amanda back to North Carolina to teach studio art at Cherokee High School.
She kept that position for almost four decades and has taught wood carving to over 2000 students. Her sculptures were often animal figures, and she was particularly known for her expressive bears.
Her work is streamlined, highly stylized, and smoothly carved. She has worked with stone and clay, but wood has been her favorite media and she carved with local woods such as wild cherry, buckeye, and black walnut.
Her art is sometimes compared to the work of Willard Stone.
Art scholar, Esther Bockhoff writes that Amanda Crowe was "undoubtedly one of the primary influences on the resurgence of Cherokee carving." Public collections that own her work include the Cleveland Museum of Natural History, the United States Department of the Interior, and the National Museum of the American Indian. She has exhibited her work in museums such as the Art Institute of Chicago, the Atlanta Art Museum, the Denver Art Museum, the Mint Museum of Art in Charlotte, the Asheville Art Museum, and venues in Germany and the United Kingdom. She also illustrated the book, Cherokee Legends and the Trail of Tears, first published in 1956 and reprinted several times since.
Amanda died in 2004.
Many of the contemporary Eastern Band Cherokee sculptors today have studied under her.