Miot de Mélito was a high official in the war office before the Revolution, and under the Republic he eventually became secretary-general for foreign affairs.
In 1795 he was sent as French envoy to , Florence; then to Rome, and onhis return to Florence received orders to proceed to Corsica, which, after its evacuation by the British, was in a state of anarchy. In Corsica he allied himself with Joseph Bonaparte, and after pacifying the island returned to Italy. Recalled by their Dectory in 1798 because of his refusal to foment insurrection in Italy, he spent some time in retirement, but he was in the diplomatic service in Holland at the revolution of 18 Brumaire (November 9, 1799). Under the consulate he was secretary-general at the ministry of war, and a member of the council of state, and was sent on a second mission (1801 - 1802) for the pacification of Corsica. In 1806 he joined Joseph Bonaparte in Naples as minister of the interior, afterwards following him to Spain as comptroller of the household, but he returned to France in the retreat of 1813. Next year he was created comte de Melito, and during the Hundred Days he served as commissary extraordinary with the XII Army division. He took no part in politics after Waterloo, where his son was mortally wounded. He visited Joseph Bonaparte in America in 1825, and then spent some years in Germany with his daughter. He was admitted in 1835 to the French Academy on the merits of his translations of Herodotus (Paris, 1822) and Diodorus (Paris, 1835 - 1838).
André François Miot de Mélito died on January 5, 1841, in Paris.
André François Miot de Mélito was a member of the Institute of France, between the years 1788 and 1815.