Background
Yakovlev, Andrej Yurij was born on November 30, 1944 in St. Petersburg, Russia. Son of Yurij Sergey and Lucia Iosif (Gornovskaya) Yakovlev.
(The search for ways to overcome tumour radioresistance is...)
The search for ways to overcome tumour radioresistance is a major problem of experimental and clinical radiation oncology. The diffi culties involved in the attempts to solve this problem are a matter of common knowledge. In many a laboratory extensive studies are un derway of factors determining tumour tissue response to irradiation and of methods for exerting directional effect upon those factors. Such studies have revealed that, at least at the cellular level, a considerable number of factors manifest themselves which are respon sible for radiation effect (1 Among those are: spatial heteroge neity of tumour cell population producing radioresistant cell reser ves (hypoxic cells of solid tumours); differing radiosensitivities of cell life cycle phases; intrinsic dynamics of the processes of radi ation damage and postradiation cell recovery; induction of prolifera tive processes in response to the death of some cells within the po pulation; the stochastic nature of cell kinetics and complicated in teraction between individual cell subpopulations corresponding to di fferent tumour loci. Questions arise as to whether the researchers are now in possession of adequate means for interpreting experimental findings and clinical evidence and whether there are procedures for performing complex analysis and predicting specific tumour responses to various irradiation regimens and to combined antitumoral effects, taking into account the complexities of the phenomena under study.
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Yakovlev, Andrej Yurij was born on November 30, 1944 in St. Petersburg, Russia. Son of Yurij Sergey and Lucia Iosif (Gornovskaya) Yakovlev.
Doctor of Medicine, 1st Leningrad Medical School, 1967; Doctor of Philosophy in Biology, Pavlov Institute Physiology, 1973; Doctor of Science in Physics and Mathematics, Moscow State University, 1981.
Research fellow, Institute Biophysics, Leningrad, 1967-1971;
research fellow, Special Design Office of Biocybernetics, Leningrad, 1971-1975;
senior research fellow, Control Research Institute Roentgenology and Radiology, Leningrad, 1975-1978;
head department biomathematics, Control Research Institute Roentgenology and Radiology, Leningrad, 1978-1988;
head department applied mathematics, St. Petersburg Technology U., 1988-1992;
professor, St. Petersburg Technology U., 1992-1996;
professor Huntsman Cancer Institute, U. Utah, since 1996. Visiting professor department statistics Ohio State University, Columbus, 1995-1996, U. Paris V,1991, University of California, Santa Barbara, 1994. Visiting researcher Institute Curie, Paris, 1992-1994.
Visiting scientist Nuclear Center Karlsruhe, Germany, 1994-1995.
(The search for ways to overcome tumour radioresistance is...)
Fellow Council Fellows of Collegium Ramazzini. Member Russian Academy Natural Sciences, European Study Group for Cell Proliferation.
Married Nina Vladimir Koulintsova, April 10, 1991. Children: Yakovlev Michail, Yuri.