Serafini graduated from North Hagerstown High School in Hagerstown, Maryland. After high school he went to Shippensburg University in south central Pennsylvania where he received a degree in Business Administration in 1983. He also briefly played football there.
After college, Serafini was a pricing analyst for Van Kampen Merritt from 1984 until 1985. He was a financial advisor for Lincoln Investment Planning from 1985 until 1990. Since that time he has been the President of Serafini Financial Services, Inc. in Hagerstown.
In addition to his work, Serafini is also active in many organizations. He was the chair of the Board of Trustees for Grace Academy (where he coached the boys' varsity soccer team to a national title), in Hagerstown from 2005 until 2007 and has been the vice-chair since 2008. He is the District Chair of the Christian Business Men's Committee, and was the Finance Campaign Chair for John F. Barr, the President of the Board of County Commissioners of Washington County in 2006.
He was assigned to the Ways and Means Committee and the Environmental Matters Committee. On February 2, 2015, Serafini was sworn into the Maryland State Senate to replace Christopher Shank who resigned to become director of the Governor's Office of Crime Control and Prevention. 2014 Race for Maryland Maryland House Of Delegates – District 2A Voters to choose two: 2010 Race for Maryland Maryland House Of Delegates – District 2B Voters to choose one:.
He is a member of the Maryland Senate from District 2 in Washington County. He is a former member of the Board of Trustees for the Maryland/Southern Delaware Chapter of the Crohn's and Colitis Foundation. Serafini took the oath of office to become a member of House of Delegates on the afternoon of March 7, 2008.
He is also a member of the Washington County and Western Maryland Delegations as well as a member of the Maryland Rural Caucus.
Married; 4 children.