She is best known for her roles in Bye Bye Birdie (1963), Viva Las Vegas (1964), The Cincinnati Kid (1965), Carnal Knowledge (1971), and Tommy (1975). She has won five Golden Globe Awards and been nominated for two Academy Awards, two Grammy Awards, a Screen Actors Guild Award, and six Emmy Awards. In 2010, she won her first Emmy Award for her guest appearance on Law & Order: SVU.
She has been married to Roger Smith since May 8, 1967; he was an actor who later became her manager. Smith is now semi-retired due to myasthenia gravis.