As the only child of Maximiliaan van Egmond and Françoise de Lannoy, she was suo jure Countess of Buren and Lady of Egmond. She was also Countess of Lingen and of Leerdam, and Lady of IJsselstein, of Borssele, of Grave, of Cranendonck, of Jaarsveld, of Kortgene, of Sint Maartensdijk, and of Odijk. By William she had three children:
Countess Maria of Nassau (22 November 1553 – after 23 July 1555), died in infancy
Philip William, Prince of Orange (19 December 1554 – 20 February 1618), married Eleonora of Bourbon-Condé, no issue
Countess Maria of Nassau (7 February 1556 – 10 October 1616), married Count Philip of Hohenlohe-Neuenstein, no issue
Anna died and was buried in Breda.
