In 1590 the couple moved in with Louis"s father, Albert in Ottweiler. In 1593 Louis took over the government in Nassau-Weilburg. Anna Maria helped organize the poor relief and set up a court pharmacy.
In 1626 Anna Maria fled from the plague from Saarbrücken to Neunkirchen where she died of the plague.
Anna Maria was buried in the crypt of the collegiate church of Saint Arnual in Saarbrücken. William Louis (1590–1640), Count of Nassau-Saarbrücken
married in 1615 princess Anna Amalia of Baden-Durlach (1595-1651)
Anna Sabine (1591–1593)
Sophie Amalie (1594–1612)
Georg Adolf (1595–1596)
Luise Juliane (1598–1622)
Karl Ernst (1600–1604)
Marie Elisabeth (1602–1626)
married in 1624 Count Frederick X of Leiningen-Dagsburg (1593-1651)
John (1603–1677), Count of Nassau-Idstein
married firstly in 1644 Princess Magdalene Sibylle of Baden-Durlach (1605-1644)
married secondly in 1646 Countess Anna of Leiningen (1625-1668)
Ernest Casimir (1607–1655), Count of Nassau-Weilburg
married in 1634 Countess Anna Maria of Sayn-Wittgenstein (1610-1656)
Otto (1610–1632), Count of Nassau-Weilburg in Neuweilnau.