Background
Anna was the daughter of Manuel Angelos Philanthropenos, Caesar of the Byzantine Empire and governor of Thessaly.
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Anna Philanthropene
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Manuel ruled Thessaly from c. 1390 until it was conquered by Bayezid I of the Ottoman Empire in 1394. Gulkhan-Eudokia of Georgia, Manuel"s first wife and consort of Trebizond died 2 May 1395.
The combined wedding took place the following day in Trebizond.
The ambassador to Tamerlane, Ruy Gonzáles de Clavijo met Manuel III and his family April 1404 while passing through Trebizond, and alludes to Anna Philanthropene as being alive. Manuel died on 5 March 1417.
Whether Anna survived him is unknown. Thierry Ganchou claims to have identified a son of Manuel and Anna, who was alive as late as 1423, and old enough to marry Eudokia, the daughter of the protostrator Manuel Palaiologos Kantakouzenos.
