She was born in 1884 to William Weightman, "the quinine king," and Louisa Stellwagen, and lived with her family at Ravenhill, in the East Falls section of Philadelphia. In 1880, Anne Weightman and her husband moved to Williamsport, Pennsylvania where her father purchased thousands of acres and real estate after Peter Herdic"s financial collapse.
Walker died on December 19, 1903, in Philadelphia, leaving her a $10 million inheritance. At the death of her father in 1904, Anne solely inherited Ravenhill, a $60 million valued estate, his properties in Williamsport, and a partnership in his drug company. Anne moved to Manhattan, New York, for her safety.
In May 1907, she commissioned Adolfo Müller-Ury to paint a portrait of Pope Pius X (now at the Graduate House at the North American College in Rome).
To celebrate her wedding she gave $1 million to charity. She also donated money and property to family members, World War I relief funds, art communities, and Catholic organizations.
She died on February 25, 1932 in Manhattan.
