Antonios was born in July 12, 1927 in the town of Hembrti, north of Asmara in the province of Hamasien. His father was a priest and he gave two of his children as a gift to the Monastery of Abune Endrias (Andrews). Both children grew up in the monastery and became monks when they become adults.
He grew up in the Monastery while being educated for the service of the church, and became a monk.
He was forcefully deposed by the Eritrean government in 2007. Abune Antonios is the fifth born child from a family of six, and he entered the monastery of Debre Tsege Abune Endrias at the age of five. He was ordained priest in 1942, and later elected Abbot in 1955.
Following the death of Abune Yacob in 2003, he was elected Patriarch in popular elections which were unanimously endorsed by the Holy Synod of the church.
His ordination and enthronement as Patriarch took place on 23 April 2004 in Asmara, at the hands of Pope Shenouda III, assisted by Eritrean and Coptic Orthodox Metropolitans and Bishops. Patriarch Antonios protested increasing interference by the Eritrean government, resulting in tensions.
In January 2005 the Patriarch"s annual Nativity message was not broadcast or televised and the Eritrean Holy Synod met on 6–7 August 2005 with the purpose of removing all executive authority from the Patriarch. The Holy Synod allowed him to officiate at church services, but prohibited him from having any administrative role in church affairs
At first, the government denied asking for his removal pointing to the fact that he was performing certain ceremonial functions.
But it kept him under virtual house arrest at his residence in Asmara. A church delegation travelled to Egypt on 25 July 2005 to seek the support of Pope Shenouda, in deposing and replacing him as Patriarch. Shenouda III refused to recognise this as a canonical act and urged the faithful to pray for Patriarch Antonios who "is passing through a great tribulation.
We hope that the Lord will rescue him".
On 13 January 2006, a secret session of the Holy Synod was held in Asmara which formally removed the Patriarch from office and his detention was tightened to ensure he remained incommunicado. On 20 January 2007, two priests accompanied by government security agents entered the Patriarch"s residence and confiscated his personal pontifical insignia.
On 27 May 2007 he was replaced as Patriarch by Abune Dioskoros, with the supported of the Eritrean government. Patriarch Antonios remains under house arrest and strict surveillance and held without charge.
He reportedly seldom receives visitors, including relatives, and has no telephone service.
His removal at the behest of the Eritrean government was denounced by the other Oriental Orthodox Churches, who have refused to recognize Abune Dioskoros as Patriarch of Eritrea.
