He attended Furman University in Greenville, South Carolina and graduated with a degree in psychology.
He was a star player on the Furman football team Browder appeared as a recurring guest on the United States. television show Party of Five as Sam Brody in its 3rd season in 1997. Buller played several guest roles on the show.
The two returned to the United States in 2003 following the cancellation of Farscape.
He appeared in the 2004 movie A Killer Within, co-starring C. Thomas Howell and Sean Young. Also in 2004, he portrayed fellow actor Lee Majors in the made-for-television film Behind the Camera: The Unauthorized Story of Charlie"s Angels.
He returned to play John Crichton in the 2004 SciFi Channel mini-series Farscape: The Peacekeeper Wars. The mini-series wrapped up the remaining plotlines of Farscape, while leaving open the possibility of future adventures.
October 2003 marked the audiobook release of Interlopers, a novel written by Alan Dean Foster and narrated by Browder.
In January 2005, Browder voiced the character Bartholomew Aloysius "Bat" Lash in an episode of the animated series Justice League Unlimited entitled "The Once and Future Thing, Participant 1: Weird Western Tales". Browder returned to the SciFi Channel as he joined the cast of Stargate SG-1 for its ninth season in 2005. He played the character of Lieutenant Colonel Cameron Mitchell, the new commanding officer of SG-1.
Browder"s former Farscape co-star Claudia Black appeared on SG-1 in the eighth season episode entitled "Prometheus Unbound" and again during the first episodes of the ninth season before becoming a regular cast member on the series at the beginning of its tenth season in 2006.
Several episodes of Stargate SG-1, most notably "200", comically alluded to Farscape during Browder and Black"s time on the series. In addition to being a series regular on Stargate SG-1, Browder also performed the majority of his own stunts.
In 2012 Browder was cast in series 7 of Doctor Who, "A Town Called Mercy". lieutenant was filmed in Almeria, Spain in March 2012.
Browder played the role of Max the Janitor in the 2012 live-action feature film Bad Kids Go to Hell, based on the graphic novel of the same name.
He will reprise the role, as well as make his directorial debut, in the 2016 sequel Bad Kids of Crestview Academy.