He attended The Kiski School and was a veteran of World War I.
He is considered to be one of the best college football players in Washington & Jefferson College history. As a fullback for Washington & Jefferson for was named to the 1926 College Football All-America Team and the 1927 College Football All-America Team. After graduation, he turned down an offer from Pete Henry to play for the New York Giants and a minor league baseball contract.
He returned to coach the Washington & Jefferson College football team from 1929 to 1931, amassing a record of 17–8–3.
From 1937 through 1946, he was a multi-sport coach at Washington High School. He was a driving force in the creation of PONY Baseball and Softball.
He also volunteered at the Brownson House. In 1932, Amos was seriously injured in an automobile collision, sustaining a fractured skull and broken left arm.
Bill Amos died in 1987 at the age of 88.