Zane was born in Chicago, Illinois, the son of Thalia and William George Zane, Sr., both of whom were amateur actors and founders of a school for medical technicians.
He has an older sister, Lisa Zane, who is an actress.
Zane was married to actress Lisa Collins from 1989, until the couple divorced in 1995. He also was engaged for a time to Chilean actress, Leonor Varela, his costar in the 1999 television film Cleopatra.Zane was engaged to marry British model turned actress, Kelly Brook, whom he met in 2005 when starring with her in the movie Survival Island, also known as Three.They split in April 2008, got back together again shortly thereafter, then ended the relationship in August 2008. Zane dated the Croatian model Jasmina Hdagha in 2010, but they broke up later that year.Through a friend he met Candice Neil an American model.Zane and Neil are parents to Ava Katherine who was born on February 20, 2011.