She attended the University of Oklahoma College of Arts & Sciences, obtaining her bachelor"s degree in 1965 and her master"s in 1970.
Her work includes Body Heat (1981), East.T. the Extra-Terrestrial (1982), and The Big Chill (1983). Carol Littleton was the recipient of an Emmy Award for Outstanding Single Camera Picture Editing (for a television Miniseries, Movie or a Special) for Tuesdays with Morrie (1999). Her obsession with film editing started in France, when Littleton became acquainted with French New Wave cinema.
During the 1970s, Carol Littleton owned a production company which made commercials.
She moved into working as a film editor with director Karen Arthur on Legacy (1975). Commencing with Body Heat (1981), Littleton had an extended collaboration with the director Lawrence Kasdan.
Of the ten films that he has directed, Littleton has edited eight, including The Accidental Tourist (1988). In the late 1980s, Carol Littleton was elected and served as the president of the Motion Picture Editors Guild.
Littleton is one of the major editors that author Gabriella Oldham interview for her book, First Cut: Conversations with Film Editors (1992).
1983 – East.T. the Extra-Terrestrial (nominated) Best Film Editing.
Littleton has been elected as a member of the American Cinema Editors.