The wedding took place at Castle Lorenzen in Nassau. This marriage produced four children:
Caroline Henriette Christine (1721–1774), called "the great landgravine"
married to Landgrave Louis IX of Hesse-Darmstadt
Christian IV (1722–1775), Count Palatine and Duke of Palatinate-Zweibrücken
Frederick Michael (1724–1767), Count Palatine of Birkenfeld
From 1744 to 1774 she lived at Bergzabern Castle. She died on 25 March 1774 in Darmstadt at the age of 69.
Her grave is in the City Church in Darmstadt.