Catherine tried to improve the fate of the poor and the needy. She built a dairy in Wedding and sold its produce on the Molkenmarkt ("Milk Market"), a square in Berlin. She used the proceeds to finance a pharmacy in the Stadtschloss that provided medicine free of charge to those in need.
Catherine died on 30 September 1608.
On 13 October, she was buried in the Hohenzollern crypt (now part of the Berliner Dom).