Career
In March 1718, Lady Mary Wortley Montagu had Maitland, who was then serving in the British embassy in Constantinople, Turkey, inoculate her five-year-old son Edward. The process was done by an elderly Greek woman from Pera under Maitland"s direction. Maitland reluctantly agreed if there were other witnesses present, so three physicians from the Royal College of Physicians were there for the procedure, the first professional inoculation in England.
One of the witnesses, James Keith, was so pleased by the success that he had Maitland inoculate his six-year-old son.
Keith"s other children had all died of smallpox. The Montague family promoted inoculation in England, calling it a "useful invention".
On 9 August 1721, Maitland received a Royal License that allowed him to test variolation on six prisoners from Newgate Prison. The experiment took place in August 1722, under the direction of Sir Hans Sloane.
All prisoners survived, and they were pardoned later that year.
One prisoner who was exposed to the disease proved to be immune. In late 1722, Caroline of Ansbach ordered the inoculation of five orphans of Saint James"s Parish in London. The surgeon died in Aberdeen, Scotland in 1748.