Radogno was educated in the Chicago area. She graduated from Lyons Township High School.
She received both her Bachelor"s and Master"s degree in Social Work from Loyola University Chicago. Before entering politics, she worked as a social worker at Mercy Center for Health Care Services. Her interest in politics began when she decided to prevent the opening of a fire station on her street, and Radogno ran successfully for Village of LaGrange Trustee (1989–1996).
In 1996, she ran for the Illinois State Senate and narrowly defeated incumbent Robert Raica in the Republican primary.
In 2006, she was the Republican nominee for Illinois State Treasurer and was defeated by Democrat Alexi Giannoulias. Her committee memberships includes:
Committee on Rules (Minority Spokesperson)
Human Services (Minority Spokesperson)
Commission on Government Forecasting and Accountability.
She currently serves as the Minority Leader, the first female leader of a political party in the Illinois Legislature.
Married Nunzio Radogno. 3 children.