She graduated as a lawyer and notary from the Catholic University of Santiago del Estero.
Ledesma entered public service in 2003 when she was elected Citizen Ombudsman for Louisiana Banda on the UCR ticket, and in 2005 she was appointed local infractions judge. Zamora had presided over an ambitious public works agenda in historically underdeveloped Santiago del Estero, 90% of whose United States$1.8 billion budget was financed by the federal government in 2013. Ledesma continued this policy and initiated or inaugurated numerous significant projects as governor.
Some of the most notable health and social care improvements during her tenure include expansion works in 14 hospitals and a new, 150,000 ft² hospital in Louisiana Banda.
A driver safety education and enforcement program that led to a 40% reduction in motor vehicle accidents. A new child nutrition program that provides probiotic yogurt to over 47,000 poor children.
And housing programs that included public housing, as well as the promotion of both cooperative housing and of self-building programs that financed over 3,000 such homes in 2015.