Background
Cobelli, Claudio was born on February 21, 1946 in Bressanone, Bolzano, Italy. Son of Paolo and Renata (Zanolini) Cobelli.
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book
The Mathematical Modeling of Metabolic and Endocrine Systems: Model Formulation, Identification, and Validation (Applied Mathematics Series)
(Introduces the concepts, methods and techniques of model ...)
Introduces the concepts, methods and techniques of model formulation, identification, and validation as applicable to metabolic and endocrine processes. Shows how modeling can be used to provide a concise description of complex dynamic processes, to test hypotheses concerning physiological and biochemical structure, and to estimate physiological quantities (parameters) that otherwise would not be directly accessible to measurement. Includes numerous examples and case studies.
http://www.amazon.com/gp/product/0471086606/?tag=2022091-20
(Tracer Kinetics in Biomedical Research: From Data to Model) Author: Claudio Cobelli published on (January, 2001)
http://www.amazon.com/gp/product/B00Y2QV4PI/?tag=2022091-20
Tracer Kinetics in Biomedical Research: From Data to Model
(The use of mathematical modeling techniques in biomedical...)
The use of mathematical modeling techniques in biomedical research is playing an increasingly important role in the understanding of the pathophysiology of disease processes. This includes not only understanding mechanisms of physiological processes, but also diagnosis and treatment. In addition, its introduction in the study of genomics and proteomics is key in understanding the functional characteristics of gene expression and protein assembly and secretion. Finally, with the increasing complexity and associated cost of drug development, modeling techniques are being used to streamline the process. This book is designed to give the reader the mathematical and statistical information necessary to design tracer kinetic studies, to use noncompartmental methodologies and/or to develop multicompartmental models to interpret the data. The book starts with a review of fundamentals of radioactive and stable isotope tracer kinetics and then proceeds with a description of the noncompartmental and multicompartmental modeling methodologies to study systems in the steady state. The focus is on understanding the basic assumptions inherent in the methodologies and the underlying mathematics and statistics, on discussing how to assess how 'good' a model is and on giving some hints on how better to design kinetic studies, in order to increase the probability of a successful study and to ensure the maximal information content in the experimental data to be extracted. The book has an extensive section on parameter estimation, i.e., fitting models to data, first in general terms and then specifically related to noncompartmental and compartmental models. This is written from a basic point of view, and is intended to remove the mystery from the 'black box' of computer optimization software. Finally, a special application often found in tracer kinetic analysis, precursor-product relationships, is discussed. Throughout the book, the goal is to provide even the novice with sufficient background so that he/she can feel comfortable. A number of case studies, based upon real experimental data, are carried through the text. Other examples illustrate specific points. All data examples are provided on a floppy disk.
http://www.amazon.com/gp/product/0306464276/?tag=2022091-20
- Modelling and Control in Biomedical Systems 1988 (This volume provides a complete and up-to-date review of ...)
Claudio Cobelli
Edit ProfileEducation
Electrical engineer, University Padua, Italy, 1970.
Career
Research scientist Italian National Research Council, Padua, 1970-1981. Professor biomedical engineering University Padua, since 1981, chairman Doctor of Philosophy bioengineering program, since 2001.
Achievements
Works
book
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Modelling and Control in Biomedical Systems 1988
(This volume provides a complete and up-to-date review of ...)
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Tracer Kinetics in Biomedical Research: From Data to Model
(The use of mathematical modeling techniques in biomedical...)
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The Mathematical Modeling of Metabolic and Endocrine Systems: Model Formulation, Identification, and Validation (Applied Mathematics Series)
(Introduces the concepts, methods and techniques of model ...)
- (Tracer Kinetics in Biomedical Research: From Data to Model) Author: Claudio Cobelli published on (January, 2001)
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Modelling and Control in Biomedical Systems 1988
Membership
Chairman technical commission on modeling and control of biomedical systems Internat.Fedn. Automatic Control, Laxenburg, Austria, since 1990, Italian National Research Council Bioengring. group, Rome. Member Institute of Electrical and Electronics Engineers, International Measurement confederation, International Federation for Medical and Biological Engineering, European Association Study of Diabetes, biomedical Engineering.Soc., Society for Mathematics Biology, American Diabetes Association.
Connections
Children: Benedetta, Francesco.
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Born
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Nationality
Italian -
Ethnicity
Education
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1970