After he graduated from California High School in Whittier, California, he attended the California Institute of the Arts (CalArts), where he honed his animation skills and met his classmate Genndy Tartakovsky, with whom he would occasionally collaborate throughout his career.
He is best known for creating the Emmy-winning animated series The Powerpuff Girls and Foster"s Home for Imaginary Friends for Cartoon Network, as well as writing and storyboarding for Dexter"s Laboratory. His newest series, Wander Over Yonder, premiered on Disney Channel on August 16, 2013. He has been married to fellow animator Lauren Faust since 2004.
McCracken got involved in drawing at an early age.
During his first year, he created a series of short cartoons featuring a character named Number Neck Joe, which were picked up by Spike and Mike"s Sick and Twisted Festival of Animation. While at CalArts, he also created a short entitled Whoopass Stew!, which would later become the basis for The Powerpuff Girls.
In 1993, McCracken was tapped by Hanna-Barbera Cartoons to be an art director on the Turner Broadcasting System series 2 Stupid Dogs, where he would also work with Tartakovsky. While at Hanna-Barbera, studio president Fred Seibert began a new project: an animation incubator consisting of 48 new cartoons running approximately seven minutes each.
Dubbed What a Cartoon!, it motivated McCracken to further develop his Whoopass Girls! creation, renaming it The Powerpuff Girls in the process.
His new pilot, "The Powerpuff Girls in: Meat Fuzzy Lumkins", premiered on February 20, 1995, on Cartoon Network"s World Premiere Toon-In, and a second short, "Crime 101", followed on January 28, 1996. The first short to be picked up by the network was Tartakovsky"s Dexter"s Laboratory, which McCracken would contribute to in early seasons. McCracken"s Powerpuff was the fourth cartoon to be greenlit a full series, which premiered on November 18, 1998.
In 2002 McCracken directed The Powerpuff Girls Movie, a prequel to his series, but it did worse than expected at the box office.
lieutenant premiered with the 90-minute television special "House of Bloo"s" on August 13, 2004, on Cartoon Network. He developed the series with wife Lauren Faust.
The show ran for six seasons, all directed by McCracken, and concluded on May 3, 2009. In April 2008, he became executive producer of a new Cartoon Network showcase project called The Cartoonstitute.
After 15 years of employment, he resigned from Cartoon Network and created Wander Over Yonder for Disney Television Animation and the Disney Channel in 2013.