Ferguson attended Freeport High School in the Long Island village of Freeport, New York. He chose Virginia over Michigan State.
He played college football for the University of Virginia and received All-American honors. He was picked by the Jets fourth overall in the 2006 NFL Draft, and has been selected for the Pro Bowl three times. He nearly gave up football during his freshman year in high school.
Considered a three-star recruit by Rivals.com, Ferguson was ranked as the No. 29 offensive guard prospect in the nation. While attending the University of Virginia, Ferguson played for the Virginia Cavaliers football team.
He started his college career listed at 260 pounds (118 kg), often dropping to 245 pounds (111 kg) through the regular season. He started 49 games for the Cavaliers, and he was named to the consensus All-America first team during his final season. He was placed on the all-Atlantic Coast Conference first team two years in a row, and he became Virginia's first All-ACC offensive tackle since 1998.
Ferguson started at left tackle in four consecutive bowl games for the Cavaliers. He played linebacker on a special defensive package employed sparingly in 2003. He did this while earning a religious studies degree in only 3.5 years.
He was an All-America selection in 2004 by Pro Football Weekly. 2006 NFL Draft
Considered an undersized tackle after playing at 295 pounds during his senior year at Virginia, Ferguson officially weighed in at 312 for the NFL combine. As a tackle, Ferguson's talent is found in his lower body strength, athleticism and flexibility.
Adding to that ability is his natural build, as Ferguson has an armspan of 87 inches (221 cm). Ferguson was one of six players the NFL invited to New York for the 2006 NFL Draft events. He was selected 4th overall by the New York Jets.
The last time the Jets used their first pick on a tackle was 1988, when they selected Dave Cadigan of USC at No. 8. New York Jets
Ferguson was drafted by the New York Jets with the 4th overall pick of the 2006 NFL Draft. On July 26, 2006, Ferguson signed a five-year deal with the Jets.
The deal was similar to the $35 million deal that 2005’s No. 4 pick, Cedric Benson, signed with the Chicago Bears. Designated as Jason Fabini's successor, Ferguson started every game at left tackle for the Jets since the beginning of the 2006 NFL season.
On January 8, 2010 Miami Dolphins Tackle Jake Long withdrew from the 2010 Pro Bowl due to injuries and Ferguson was named as his replacement. He was invited to the 2011 Pro Bowl. Ferguson's given name was inspired by Father Ralph de Bricassart, a fictional character in the 1977 novel The Thorn Birds.
Ferguson's hometown of Freeport, New York, dedicated a street to him on September 29, 2009. South Ocean Avenue, where he grew up, received secondary signage as D'Brickashaw Ferguson Way. Ferguson married Kirsten Speller on July 2, 2011.
He is also a black belt in Karate. Ferguson was the inspiration for Key & Peele's East-West College Bowl sketch, where Key and Peele imitate football players with humorous names and introduce themselves. In the most recent version of said Bowl, real players including D'Brickashaw were used.