He graduated from Jefferson City High School in 1908 and received a Bachelor of Arts degree from Carson–Newman College in 1912.
He served as the head football coach at Mississippi College (1913–1915), Louisiana State University (1916), Texas Agricultural and Mechanical University (1917, 1919–1928), the University of Nebraska (1929–1936), and the University of Texas (1937–1946), compiling a career college football record of 198–72–23. Bible was also the head basketball coach at Texas Agricultural and Mechanical from 1920 to 1927 and the head baseball coach there from 1920 to 1921. In addition, he was the athletic director at Nebraska from 1932 to 1936 and at Texas from 1937 to 1956.
Bible was inducted into the College Football Hall of Fame as a coach in 1951.
Bible began his coaching career at Brandon Preparatory School in Shelbyville, Tennessee. Mississippi College recruited him to coach in 1912, and he was recruited to coach for Texas Agricultural and Mechanical University in 1916.
In his college football coaching career, Bible compiled a record of 198–72–23. His teams had winning records in thirty of the thirty-three seasons he coached.
Bible also coached baseball and basketball at Texas Agricultural and Mechanical. During his hiatus from Texas Agricultural and Mechanical in 1918, Bible served as pilot in World War I.
In ten seasons at Texas, Bible brought the Longhorns football program to national prominence, winning three Southwest Conference championships, making three appearances at the Cotton Bowl Classic (two victorious), and placing in the final Associated Press Poll rankings five times.
While at Texas, University of Chicago coach Clark Shaughnessy contacted Bible to organize a clinic on the T formation. Along with Frank Leahy of Notre Dame, they helped create the T formation revolution. Bible was elected to the College Football Hall of Fame in 1951, the Texas Sports Hall of Fame in 1959 and the Longhorn Hall of Honor in 1960.
Bible served on the National Collegiate Football Rules Committee for 25 years, and was president of the American Football Coaches Association.
His book, Championship Football, was published in 1947. Bible was the son of Jonathan David Bible (October 9, 1863 in Cocke County, Tennessee – November 23, 1942) and Cleopatra I. Willis (October 19, 1870 – January 25, 1954).
The couple married on June 20, 1889. Jonathan was a college professor at Carson–Newman College in Jefferson City, Tennessee, he could quote biblical scripture and was a Greek and Latin scholar.
Bible married Rowena Rhodes on December 19, 1923.
They had two children, William and Barbara. Rowena died in 1942.
Bible died on January 19, 1980, and is interred at Austin Memorial Park Cemetery in Austin, Texas.
Bible played football while in college and was a member of Delta Kappa Epsilon fraternity, Iota chapter.