The Twins signed Santana as an undrafted free agent in December 2007. In November 2012, the Twins added Santana to the 40 man roster in order to protect him from the teams who wanted him. 2014
Santana was called up to the major leagues for the first time on May 2, 2014.
After a solid start to his career, Santana was placed on the 15-day disabled list on June 27, 2014.
Additionally, Santana"s rookie year batting average of.319 is a Twins franchise record (minimum 130 ABs).