He attended primary school there. His family later moved to Christchurch, where Low briefly attended Christchurch Boys' High School. However following the death of his eldest brother, Low was taken out of school, as his parents believed that he had been weakened by over studying.
Low's first cartoon was published in 1902, when he was 11 years old, a three-picture strip in the British comic Big Budget.
At the age of fifteen Low began to have his drawings published in magazines and newspapers in New Zealand. This included anti-gambling cartoons for the War Cry, the newspaper of the Salvation Army, and illustrations for New Zealand Truth, a weekly newspaper specializing in sensational crime and sex . Still a teenager, Low was appointed the regular political cartoonist of the New Zealand Spectator. His fame spread to Australia and at the age of eighteen he was asked to join the Sydney Bulletin, where he worked with two other great cartoonists, Livingstone Hopkins and Norman Lindsay.
The British writer Arnold Bennett was impressed when he saw Low's cartoons and wrote an article about him in the New Statesman. This resulted in Low being offered a job in England with The Daily News and the company's evening paper, the Star. Low arrived in England in 1919 but was unhappy with the space that he was given for his cartoons. After threatening to resign, the editor of the Star agreed to publish the large, half-page cartoons that he had been doing in Australia. In London Low became a close friend of the other great political cartoonist of the period, Will Dyson of the Daily Herald.
Low was commissioned by the Star to draw the portraits of the fifty most distinguished people in Britain. His subjects included George Bernard Shaw, Arnold Bennett, H. G. Wells, Hilaire Belloc, G. K. Chesterton and Arthur Conan Doyle. Only two men refused to sit for him: John Galsworthy and Rudyard Kipling. After a disagreement with the editor about how this should be presented in the Star, Low eventually had them published in the New Statesmen. Low also had cartoons published in other journals in Britain such as Punch Magazine and The Graphic.
In 1927 Low was persuaded by Lord Beaverbrook to work at the Evening Standard. Although Beaverbrook was a strong supporter of the Conservative Party, he promised Low that he would have complete freedom to express his own radical political views. Unhappy with the political leadership of the British establishment David Low created his cartoon character, Colonel Blimp in 1934. In his autobiography, Low explained that Blimp represented everything he disliked in British politics: "Blimp was no enthusiast for democracy. He was impatient with the common people and their complaints. His remedy to social unrest was less education, so that people could not read about slumps. An extreme isolationist, disliking foreigners (which included Jews, Irish, Scots, Welsh, and people from the Colonies and Dominions); a man of violence, approving war. He had no use for the League of Nations nor for international efforts to prevent wars. In particular he objected to any economic reorganization of world resources involving changes in the status quo."
In the 1930s Low joined with other radicals, such as Stafford Cripps, Nye Bevan, Ellen Wilkinson, J. B. Priestley, Victor Gollancz, Henry Nevinson and Norman Angell to complain about Britain's foreign policy. Low was especially appalled by what he called the "Government's supine attitude to foreign intervention in Spain" during the Spanish Civil War.
Low's cartoons criticizing Hitler and Mussolini resulted in his work being banned in Germany and Italy. After the war it was revealled that in 1937 the German government asked the British government to have "discussions with the notorious Low" in an effort to "bring influence to bear on him" to stop his cartoons attacking appeasement.
Low was attacked in the press as a "war-monger". However, others welcomed his criticisms of Hitler. This included Sigmund Freud who wrote: "A Jewish refugee from Vienna, a very old man personally unknown to you, cannot resist the impulse to tell you how much he admires your glorious art and your inexorable, unfailing criticism."
Low left the Evening Standard in 1949 and later worked for the Daily Herald (1950-1953) and the Manchester Guardian (1953-1963).
Published collections of Low's work include: "A Cartoon History of the War" (1941), "Low's Company" (1952), "Low's Autobiography" (1956) and "Years of Wrath: 1932-1945" (1986).
David Low, who was knighted in 1962, died in 1963.
Low married Madeline Grieve Kenning of Auckland on 7 June 1920 in St. Paul's Church, Covent Garden. They lived for many years in Golders Green, North London. The couple had two daughters: in 1939, Time described Low's breakfast as "a political meeting, with the cartoonist, his wife, and his two young daughters threshing out the news." Low died on 19 September 1963. His wife and daughters survived him.