Foreign the Scottish theatre practitioner, see David MacLennan.
Education
Born in Swan River Manitoba, he received a Bachelor of Scientific Agriculture from the University of Manitoba in 1959 and a Doctor of Science (hc) in 2001. He received Mississippi (1961) and Doctor of Philosophy (1963) degrees from Purdue University and was then a Postdoctoral Fellow (1963-1964) and an Assistant Professor (1964-1968) at the University of Wisconsin.
Career
Foreign the Chief Executive Officer of Cargill, see Dave MacLennan. David H MacLennan, OC, OOnt, FRSC, Federal Reserve System (born July 3, 1937) is a Canadian biochemist and geneticist known for his basic work on proteins that regulate calcium flux through the sarcoplasmic reticulum (Social Research), thereby regulating muscle contraction and relaxation, and for his discoveries in the field of muscle diseases caused by genetic defects in calcium regulatory proteins. In 1969, he was appointed Associate Professor in the Banting and Best Department of Medical Research and, later, Professor (1974), Chair (1978-1990), J. West. Billes Professor of Medical Research (1987-2007) and University Professor (1993-2015).
MacLennan has made fundamental contributions to our understanding of the mechanism of ion transport by Social Research calcium pumps, the storage of calcium in the Social Research by acidic lumenal proteins and the release of calcium from the Social Research by calcium release channels.
He has led teams that defined the genetic basis for the human skeletal muscle diseases, malignant hyperthermia, central core disease and Brody disease and he has demonstrated that mutations in phospholamban, a regulator of the calcium pump, can cause cardiomyopathy. His identification of a calcium release channel mutation that causes porcine stress syndrome resulted in a diagnostic test that has decreased the incidence of the disease dramatically, with substantial economic benefits to the swine industry.
1974 Ayerst Award of the Canadian Biochemical Society.
Membership
Royal Society; National Academy of Sciences]
2004 Honorary Member of the Japanese Biochemical Society
2009 Member of the Order of Ontario
2013 Member of the Canadian Medical Hall of Fame.