Career
When Mehmet"s son Murat emerged as the victor, he was selected as one of the envoys (the other two being Matthew Laskaris and Angelos Philomattes) to meet with Murat. He played other prominent roles in diplomatic affairs as mesazon to the two emperors. He was a witness to John"s treaties with the Republic of Venice in September 1423, May 1431, October 1436, September 1442, and July 1447.
Demetrios" fate following the fall of Constantinople to Sultan Mehmet II"s army is unclear.
Donald Nicol notes that a Demetrios Kantakouzenos is recorded as escaping from the fallen city, with his family and other refugees, on the ship of the Genoese admiral Zorzi Doria. Doria took them as far as Chios, where the Venetian captain Thomas Celsi gave them passage to Candia (modern Heraklion) in Crete.