Career
Despos has spent his entire career in the Greek leagues. Despos started playing basketball in amateur club Ikaroi Trikala of his hometown, before moving to GS Larissa in 1994. In the 2007-2008 season, while with MENT, Despos lead the A2 League in rebounds with 279 in 30 games.
In July 2008 he signed for Peristeri.
In 2011 Despos signed for AEK. He stayed with the team for three years, helping them to gain promotion to the top tier. In September 2014 he signed for Iraklis of the Greek A2.
In a match against Filippos Veria, Despos exceeded 3,000 points in the Greek A2 League. During the tournament he appeared in 4 games, averaging 2.5 points and 2.8 rebounds per game.
Despos has represented Greece at youth level in 91 games, averaging 4.8 points per game.