On September 25, 2005, Larman was signed by the Florida Panthers as a free agent. Drew made his professional debut with the Panthers affiliates, the Florida Everblades of the ECHL and the Rochester Americans of the AHL, in the 2005-2006 season. Larman made his National Hockey League debut the following 2006-2007 season with the Panthers, playing in 16 games.
Drew then spent the next two seasons playing primarily for Rochester.
On July 13, 2009, Larman signed a one-year contract with the Boston Bruins. He was assigned to start the 2009-2010 season, in the AHL with affiliate the Providence Bruins.
In a checking-line role, Larman added 6 goals and 12 points in 55 games with Providence, while also featuring in 4 scoreless games in a recall to the Boston Bruins. As a free agent and with little National Hockey League interest, Larman belatedly signed a one-year contract in the ECHL with his first professional club, the Florida Everblades on November 11, 2010.
Larman played in 57 games with the Everblades, adding little offense with 11 points to draw a close to his professional playing career at the conclusion of the 2010-2011 season.