Career
He has written and appeared in sketches for two seasons of Fuel television"s Stupidface, Showtime"s Louisiana Louisiana Land, Comedy Central"s Nick Swardson"s Pretend Time, and both seasons of Home Box Office"s Funny or Die Presents. He was featured in an episode of the Funny or Die web series Drunk History titled "Tesla & Edison". His television credits include MADtv and Curb Your Enthusiasm.
He is the host of Thunderbrain, a comedy science pilot he is developing with Comedy Central.
He co-hosted The Lavender Hour podcast with Natasha Leggero through January 2012. Duncan now hosts his own podcast, The Duncan Trussell Family Hour.
On December 14, 2012, Trussell announced that he had been diagnosed with testicular cancer. The cancer was successfully treated.