Cherry emigrated from The Bahamas to the United States, and resides in Wauchula, Florida. Cherry began boxing professionally in 2001, with mixed results (3-2-2 as of July 2002). Soon after signing with Peter Fernandez and Starfight Productions he appeared to find his groove, racking up 14 straight wins and acquiring a number of minor titles—the WBC Caribbean Boxing Federation Lightweight title and the National Basketball Association Intercontinental Lightweight Title.
In February 2007 Cherry lost a unanimous decision to Paulie Malignaggi on Home Box Office. Recently, Edner Cherry has been named Friday Night Fights Boxer of the Year (2006) by Entertainment and Sports Programming Network and has fought on both Showtime and Home Box Office. Although very well prepared for this fight, Cherry dropped a unanimous decision to Bradley.
At the end of 2008, Cherry left his long-time trainer, Pete Fernandez and signed with TKO Promotions. Cherry was scheduled to fight for the NABO super featherweight title, but after the original opponent pulled out of the fight, his management was unable to find a replacement.
The fight was cancelled. In January 2012, Cherry signed a promotional deal with Chicago-based, 8 Count Promotions.
He also signed an exclusive management deal with Albert Falcon and Patrick Doljanin of Warehouse Boxing, located in Highland Park, Illinois.