Buzzell was born in Brooklyn. He appeared in Vaudeville and on Broadway, and was hired to star in the 1929 film version of George M. Cohan"s Little Johnny Jones with Alice Day. Buzzell appeared in a few Vitaphone shorts, and the two-strip Technicolor short The Devil"s Cabaret (1930) as Satan"s assistant.
He wrote screenplays in the early 1930s and later produced the popular The Milton Berle Show which premiered on television in 1948.
In 1926, Buzzell married actress Ona Munson), who later played Belle Watling in Gone with the Wind. They divorced in 1931.
He died in Los Angeles in 1985 at the age of 89.