Career
He was best known for his participation in the Exorcism of Roland Doe. Hughes participated in an exorcism in 1949 at the Georgetown University Hospital on an anonymous thirteen-year-old boy, where he was allegedly injured when the boy broke out of his restraints. William Peter Blatty was inspired by a newspaper article about this case to write his novel The Exorcist.
In 1973, Father Hughes returned to Saint James Church and became pastor until his death of a heart attack on October 12, 1980.