Bachelor of Science, Washington and Lee University, 1963; Doctor of Medicine, University of Pennsylvania, 1967.
Intern Hospital of University Pennsylvania, 1967-1968. Resident in medicine Duke University Medical Center, Durham, North Carolina, 1970—1971, 1973—1974, fellow in metabolism, 1971—1973. Professor medicine and biochemistry Duke University School Medicine, 1974-1991, chief division metabolism, endocrinology and genetics, 1983—1991.
Investigator Howard Hughes Medical Institute, 1974-1987. Professor, chairman department medicine University Pennsylvania, Philadelphia, 1991-1997. Senior associate dean research Stanford University School Medicine, 1997-2000.
Dean Duke University School Medicine, Durham, 1999—2000. Vice chancellor academic affairs Duke University Medical Center, 1999—2000. Vice chancellor health science, dean school medicine University California, San Diego, 2000—2006.
Executive deputy chairman clinical-translational science Biomedical Research Council (BMRC), executive chairman National Medical Research Council Agency for Science, Technology and Research (A*STAR), Singapore, since 2006. Lien Ying Chow professor medicine National University Singapore, since 2006.
With United States Public Health Service, 1968-1970. Member American Society Clinical Investigation, Association American Physicians.
Married Judith L. Swain, January 25, 1980.