Wilson had two sisters, Margaret Woodrow Wilson and Jessie Woodrow Wilson Sayre. They had a daughter Ellen Wilson McAdoo (1915–1946) and a second daughter, Mary Faith McAdoo (1920–1988). Because she had written a biography about her father, she served as an informal counselor on the 1944 biopic Wilson.
In 1965, she became largely incapacitated after suffering a cerebral hemorrhage.
McAdoo died at her home in Montecito, California, at 77. She was interred at the Santa Barbara Cemetery, Santa Barbara, California.
Woodrow Wilson, father
Ellen Axson Wilson, mother
William Gibbs McAdoo, former husband
Margaret Wilson, sister
Jessie Woodrow Wilson Sayre, sister.