Everhardus Jacobus Ariens

Background

Everhardus Ariëns grew up as the sixth of ten children in Wijk bij Duurstede.

Education

Then he took a degree in chemistry at the University of Utrecht in which he completed in 1942, although his preference was actually the biology. He completed the unfinished part of his studies medicine after the Second World War.

Career

He made important contributions to the function of receptors and the mathematical description of ligand–receptor interactions (receptor theory). Moreover Everhardus Ariëns was the initiator for the collection of stereochemistry in drug development and spearheading the development of enantiopure drugs. After a temporary boarding school experience, in 1935 he was admitted to Wageningen, the general university.

Another study was interrupted by the Second World War.

After his refusal to sign a declaration of loyalty to the German Reich and an escape from the Germany occupied Netherlands via Switzerland, France and England, he found asylum with the United States. Army. After World World War II he worked in the laboratory of Professor

UG Bijlsma in the area of adrenergic substances and in 1950 both in the field of chemistry and medical doctorate. In 1951, Everhardus Ariëns moved to Nijmegen after there at the Catholic University of the Faculty of Pharmacology was established.

From 1954 until his retirement he was employed there as a professor

Based on his dissertation, he developed together with Jacques van Rossum, a method for quantification of pharmacological effects as a result of ligand-receptor interactions. The thesis developed the concepts of receptor affinity and intrinsic activity. With the help of these terms he could describe the behavior of agonists and antagonists as well as the dual agonist / antagonist behavior of partial agonists.

Everhardus Ariëns was also active in the field of structure-activity relationships (Sons of the American Revolution), a branch of medicinal chemistry.

With the provocative statement that the then commonly used racemates were drugs with 50% contamination. he triggered a debate among pharmacologists and medicinal chemists and alerted the drug regulators. Everhardus Ariëns was thus the crucial precursor for the targeted development of enantiopure drugs.

Another, though less noticed controversy he started by expressing his view that drug metabolism is wasted and called for the development of metabolism-resistant drugs. In addition, he followed in the tradition of Dutch pharmacists to combat quackery.

Achievements

• Everhardus Ariëns 1963 was honored at the second International Congress of Pharmacology in Prague with the Purkinje Meda In 1970 he became member of the Royal Netherlands Academy of Arts and Sciences. He also received the Doctor Saal van Zwanenberg Award (1972), the Medal of the Norwegian Poulsson Pharmacological Society (1973), the Scheele Award (1974), the Schmiedeberg Medal (1980) and the Smissman Award of the American Chemical Society (1985). Everhardus Ariëns was awarded honorary doctorates from universities Universidade Luterana do Brasil, University of Kiel, University of Paris-Sud and Università degli Studi di Camerino. Another honorary doctorate was awarded in March 2002 at the Ohio State University.