Career
A Syrian, on 6 November 422 he was praefectus urbi of Constantinople, in which capacity he received an edict preserved in the Codex Theodosianus (vi81). After holding another high administrative post, perhaps as praetorian prefect of Illyricum, from 21 April 428 to 11 February 430 Florentius held the second office of the Empire, the praetorian prefecture of the East, receiving further the honour of the consulate in 429. In 438 (31 January) and 439 (26 November) he was again prefect for the East.
Due to the closure of brothels of Constantinople, the treasury received less revenue, and Florentius decided to give some of his own properties to the State to compensate for the loss.
In the mid-440s, he was praetorian prefect twice again, presumably for the East. In 451 he attended the Council of Chalcedon, during which he was present at the first, third, fourth and sixth sessions.
At the beginning of the reign of Marcian, Florentius and Anatolius dissuaded the emperor to support the uprising of the Armenians against the Sassanids. Marcian sent him to the Persian king to reassure Roman intention not to intervene.