She earned her Bachelor of Surgery in Mechanical and Aerospace Engineering from Princeton University in 1979 and her Doctor of Philosophy in Chemical Engineering from the University of California, Berkeley.
Postdoctoral University California, Berkeley, 1985, California Institute of Technology, Pasadena, 1986, assistant chemical engineering, 1987-1992, associate professor, 1992—1996, professor chemical engring & biochemistry, 1999, Dick and Barbara Dickinson professor chemical engineering and biochemistry. Visiting associate chemistry University California, Berkeley, 1986—1987. William Rauscher Lecturer in Chemistry Rensselaer Polytechnic Institute, 1996.
Purves Lecturer in Chemistry McGill University, 1998. Lindsay Distinguished Lecturer Texas Agricultural and Mechanical, 2003. Merck-Frosst Invited Lecturer Biochemistry University Alberta, 2003.
Sir Robert Price Lecturer Commonwealth Scientific and Industrial Research Organisation, Melbourne, 2003. Lewis lecturer Massachusetts Institute of Technology, 2006. Walker lecturer Pennsylvania State University, 2006.
Kelly lecturer Purdue University, 2006. Cruickshank lecturer Gordon Research Conferences, 2008. Linnaeus lecturer Uppsala University, 2008.
Steenbock lecturer University Wisconsin, 2008. Electrical member National Academy Engineering, 2000, Institute Medicine, 2004, National Academy of Sciences, 2008.
Member of National Academy of Sciences, National Academy of Engineering (Charles Stark Draper prize 2011), American Association for the Advancement of Science (Science Innovation Topical Lecturer), Institute Medicine, Santa Fe Institute (Science Board), American Institute Medical and Biological Engineering, American Society Microbiology, Protein Society, American Institute Chemical Engineers, American Chemical Society (David Perlman Lecturer Award, American College of Surgeons Biochemical Technology 2003, Carothers award, American College of Surgeons Delaware division 2003, Francis P. Garvan-John M. Olin medal 2005), Tau Beta Pi, Phi Beta Kappa.
Married Andrew Evan Lange, March 4, 1994. Children: James Howard, William Andrew.