He was a son of his predecessor Francesco II Gonzaga, Marquess of Mantua and Isabella d"Este. Federico Gonzaga was crowned Marquis Mantua on 3 April 1519, initially under the regency of his mother and his uncles Sigismondo and Giovanni Gonzaga.
Federico II of Gonzaga (May 17, 1500 – August 28, 1540) was the ruler of the Italian city of Mantua (first as Marquis, later as Duke) from 1519 until his death. He was also Marquis of Montferrat from 1536. He received the imperial investiture from emperor Charles V on April 7, 1521.
Despite his poor military experience, Pope Leo X named him Gonfalonier and Captain General of the Church (commander in chief of the Papal Army), though a clause allowed Frederick to avoid fighting against the Empire, to which Mantua had always traditionally been an ally.
Frederick therefore did not intervene when the Imperial troops passed through his lands in 1527, indirectly causing the subsequent Sack of Rome. Frederick had signed a marriage contract with the heir to the Marquisate of Monteferrat, Maria Palaeologina, with the aim of acquiring that land.
Its marquess Boniface IV of Montferrat was in poor health. But when Boniface seemed to recover, he set up an alleged plot on the part of Maria against Frederick"s mistress, Isabella Boschetti: this was sufficient to have the Pope cancel the nuptial contract.
Frederick then signed another marriage contract with Charles V"s third cousin, Julia of Aragon.
In lieu of this move, in 1530 he was granted the ducal title, whereby their dynasty became Dukes of Mantua. At the death of the last legitimate male heir of the Palaiologos family, Giovanni Giorgio (1533), the marquisate of Montferrat passed to the Gonzaga, who held it until the 18th century. Frederick commissioned the Palazzo Te, designed and decorated by Giulio Romano, as his summer palace just outside Mantua.
Having suffered long from syphilis, which he had inherited from his father, he died in 1540 at his villa at Marmirolo.
Frederick and Margaret were parents to seven children:.
