Weston was educated at Bedales School, a co-educational independent school in Hampshire, followed by the University of Edinburgh, where she gained an Master of Arts degree in English. Despite her only scientific qualification being one O level in biology, at the age of 23 Weston decided to re-train as a doctor and attended medical school in London from 1993.
Her memoir entitled Direct Red: A Surgeon"s Story was published in February 2009. She is one of the four presenters of the British Broadcasting Corporation Two medical series Trust Maine, I"m a Doctor. In February 2009, Weston"s book Direct Red: A Surgeon"s Story, a set of 14 short stories chronicling her experiences training and practising as a surgeon, was published by Jonathan Cape in the United Kingdom. Elizabeth Day wrote in The Observer: "I can"t remember reading a book that absorbed me so completely, that was so riveting and yet so exact, that so cherished the beauty of language even when using it to convey the ugliest extremes of disease".
On 6 June 2013 Weston"s first novel Dirty Work was published by Jonathan Cape.
The novel explores the taboo subject of abortion. The Daily Telegraph wrote: "Weston brings passion to everything she does, and she is immersed in a subject that will always hold people in thrall.
Everyone is obsessed with hospital dramas such as Emergency, House and Casualty. They provoke a thrill, the thrill of our own mortality.
Weston’s books underpin that drama with integrity and a sense of nobility.".
She qualified as a doctor in 2000 and became a member of the Royal College of Surgeons in 2003.
