Career
After making $535 from his first public demonstration of nitrous oxide, Colton left medical school to travel the country giving lectures and presentations. On December 10, 1844, he gave a performance in Hartford, Connecticut, at which one of his audience volunteers injured his leg, but did not feel the pain because of the effects of the gas. Connecticut dentist Horace Wells was in attendance, realized the possibilities of using nitrous oxide in dental surgery, and obtained a supply of the gas from Colton.
He was unsuccessful in finding gold, and Colton returned to the East.
Between 1864 and 1897, Colton and his associates used nitrous oxide in tens of thousands of tooth extractions.